Everyone seems inclined to compare this show to the Simpsons, but while it's true (and stylistically obvious) that there is some Simpson blood here, I think the show was intended to be something entirely different.
When I first watched Futurama, to be honest, I wasn't too impressed. It seemed forced, and kind of thrown together. Now that I watch it every chance I get, I think that reaction was simply a result of the fact that I had never seen a show like this one. Every one of the main characters is unique and well-developed, and often one or two will become spotlighted in any particular episode....which is generally a good strategy in writing a series, since it highlights the importance of each character without forgetting about the rest of the group. However, I must admit there are times when the jokes will fall flat for me. After all, Futurama doesn't have a brand of humor that it follows religiously. It tends to experiment with different forms--i.e. cute vs. crude, insightful vs. visual gag, etc.--every now and then. That's probably a good thing, but it also means that unless you like ALL types of humor, some of the jokes might not crack a smile. I almost gave it three stars.
But I'd say Futurma makes up for it in the end with two things: First, its creativity. Many episodes had a lot of thought and care put into them, whether in their use of real scientific theories, or just really rich writing in general. The second thing that makes up for the bad jokes...is the GOOD jokes. Some of the humor in Futurama will just put me in a fit on the floor. A personal favorite of mine is an episode in which Bender, feeling dejected and alone, wanders an empty beach in sorrow. A large aluminum sign is posted in the sand that reads, "No Boating Allowed." Without so much as a glance at the sign, Bender walks up to it, folds it into a boat, and rows away.
So in conclusion, I wouldn't say Futurama is the best show out there, but if you haven't seen whatever show IS the best show out there, you might just think the best show is Futurama.