Thanks to the miracle of modern medicine, Sherlock Holmes is brought back to life and rejuvenated in form to that of a 25-year-old. He's there to solve all new mysteries in a strange futuristic world of the 22nd Century. Sherlock's joined by a robotic Watson and a female Inspector Lestrade as well as his old nemesis in the form of a clone of the original criminal mastermind, Professor Moriarty.