Party-going alcoholic Reilly is rendered paralysed when run down by a Mort, a rich, snobbish lawyer. As part of his settlement Reilly acquires 'Maimed Manor' - a crumbling mansion right next door to the mortified Mort. After quitting the booze so his friends can stand him, he moves in here with Fontaine - a blind black man who is tone-deaf, Blazer - a relentlessly lewd head on a skateboard, and Lefty - a former masseur with hooks for hands. Soon joining the household are Reilly's gay Australian physical therapist, and Franny, his hippy girlfriend.