Like 'All Dogs to go to Heaven 2' and 'An All Dogs Christmas Carol', the series is set in present day San Francisco. It includes most of the characters from ADGTH 2 - though Charlie and Sasha's relationship is back to a 'sort of' state, Itchy and Charlie live as bachelors, David's family is nowhere to be seen, and Killer makes a return from the original movie. With the addition of a few new characters, ADGTH the Series is about Charlie and Itchy's Angelic missions, the ever-present threat of Carface, the not-quite happening romance between Charlie and Sasha, and lots more besides.